Abstract
Background: This study was to examine the patients with acute cerebral infarction (ACI) treated at a single center over 9 years and who underwent Unruptured intracranial aneurysm (UIA) screening by three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA), and to explore the factors associated with outcomes.Methods: The outcome was the modified Rankin scale (mRS) score at 90 days after stroke onset. The outcome was classified into a good outcome (mRS score of 0–2 points) and poor outcome (mRS score of 3–6 points).Results: UIAs were found in 260 (6.5%) of 4,033 patients with ACI; 2,543 (63.1%) had a good outcome, and 1,490 (36.9%) had a poor outcome. There was no difference in outcomes between the two groups (P = 0.785). The multivariable analysis showed that age (OR = 1.009, 95%CI: 1.003–1.014, P = 0.003), diabetes (OR = 1.179, 95%CI: 1.035–1.342, P = 0.013), ischemic stroke history (OR = 1.451, 95%CI: 1.256–1.677, P < 0.001), and baseline NIHSS score (OR = 1.034, 95%CI: 1.018–1.050, P < 0.001) were independently associated with the 90-day outcomes in patients with ACI. The presence of incidental UIA was not associated with outcomes after ACI.Conclusions: Age, diabetes, ischemic stroke history, and baseline NIHSS score were independently associated with the early outcomes of patients with ACI.
Highlights
Stroke is characterized by an ischemic infarction of a brain area or an abnormal collection of blood within the brain or the cranium, resulting in a focal injury to the central nervous system (CNS) and acute neurological dysfunction [1]
The multivariable analysis showed that age (OR = 1.009, 95%CI: 1.003–1.014, P = 0.003), diabetes (OR = 1.179, 95%CI: 1.035–1.342, P = 0.013), ischemic stroke history (OR = 1.451, 95%CI: 1.256–1.677, P < 0.001), and baseline National Institutes of Health Stroke Scale (NIHSS) score (OR = 1.034, 95%CI: 1.018–1.050, P < 0.001) were independently associated with the 90-day outcomes in patients with acute cerebral infarction (ACI)
Age, diabetes, ischemic stroke history, and baseline NIHSS score were independently associated with the early outcomes of patients with ACI
Summary
Stroke is characterized by an ischemic infarction of a brain area (ischemic stroke) or an abnormal collection of blood within the brain or the cranium (hemorrhagic stroke), resulting in a focal injury to the central nervous system (CNS) and acute neurological dysfunction [1]. Ischemic strokes (80–87% of strokes) usually result from cardioembolism (often from atrial fibrillation), large artery atherosclerosis leading to occlusion, occlusion of small vessels (seen in lacunar strokes), or systemic hypoperfusion [1]. The estimated global incidence of stroke is 2–3 per 1,000 person-years, with older patients and patients with carotid artery stenosis or atrial fibrillation having the highest risk [1]. In 2015, the incidence of acute cerebral infarction (ACI) in China reached 47.0 per 100,000 people [2]. This study was to examine the patients with acute cerebral infarction (ACI) treated at a single center over 9 years and who underwent Unruptured intracranial aneurysm (UIA) screening by three-dimensional time-of-flight magnetic resonance angiography (3D-TOF-MRA), and to explore the factors associated with outcomes
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