Abstract
A 59 year old patient was referred to our department to detect disease activity related to clinical symptoms of tiredness, weight loss and an elevated serum serotonine, suspicious of a neuro-endocrine tumour. A 18F-fluoro-l-dihydroxy-phenylalanine (FDOPA) PET/CT scan was performed, which showed focally increased uptake in the terminal ileum and in a mesenterial lymph node. Additionally, an area of intense uptake was observed intracranially. Histological analysis confirmed the presence of a WHO grade I meningioma. Few cases of FDOPA PET uptake in meningiomas have been published, underlining it is as a rare finding. Awareness of this potential finding is crucial to avoid misinterpretation as intracerebral metastasis.
Highlights
A 59 year old patient was referred to our department to detect disease activity related to clinical symptoms of tiredness, weight loss and an elevated serum serotonine, suspicious of a neuro-endocrine tumour
FDOPA PET has been used in the evaluation of brain tumours, among other PET techniques using amino acid tracers such as 11C-methionine and -(2-[18F]fluoroethyl)-l-tyrosine (FET) (Becherer et al 2003; Fueger et al 2010; Schiepers et al 2007)
The increased uptake of FDOPA is related to the L amino acid transporter (LAT)
Summary
A 59 year old patient was referred to our department to detect disease activity related to clinical symptoms of tiredness, weight loss and an elevated serum serotonine, suspicious of a neuro-endocrine tumour. A 18F-fluoro-l-dihydroxy-phenylalanine (FDOPA) PET/CT scan was performed, which showed focally increased uptake in the terminal ileum and in a mesenterial lymph node (Fig. 1). An area of intense uptake was observed intracranially (Fig. 2a, left frontal region). The atypical location of the uptake suggested the presence of a mengioma (Fig. 2b).
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