Abstract
IntroductionCyst infection is a known complication of autosomal dominant polycystic kidney disease (ADPKD). Here, we describe incidence, risk factors, clinical presentation, and outcomes of cyst infection in kidney transplant recipient.MethodsWe conducted a single-center retrospective cohort study of patients with ADPKD with renal allografts between January 1, 2009, and October 31, 2020. Cyst infection diagnosis was based on previously described clinical and radiological criteria, using positron emission tomography when available.ResultsA total of 296 patients with ADPKD with renal allografts were included, and 21 patients experienced 22 episodes of cyst infection over a median follow-up of 4 (2–7) years. The cumulative incidence rate was 3% at 1 year, 6 % at 5 years, and 12% at 10 years after transplantation. In multivariate analysis, history of cyst infection before transplantation was the only significant risk factor identified to predict the occurrence of cyst infection after kidney transplantation (hazard ratio [HR] 3.47, 95% CI 1.29–9.31). The clinical presentation at diagnosis of cyst infection included isolated fever in 5 (23%) episodes, acute kidney injury in 12 (55%), and severe sepsis/septic shock in 3 (14%) episodes. Among the 16 (73%) episodes with culture positivity, Escherichia coli was the most common pathogen. There was no difference between early (≤1 year after transplantation) and late (>1 year) cyst infection episodes in terms of clinical presentation and outcomes. Cyst infection was significantly associated with graft loss (HR 3.93, 95% CI 1.21–12.80), but no causal relationship could be established.ConclusionIncidence of cyst infection in ADPKD after kidney transplantation is low, history of cyst infection representing the main risk factor.
Highlights
Cyst infection is a known complication of autosomal dominant polycystic kidney disease (ADPKD)
History of cyst infection before transplantation was the only significant risk factor identified to predict the occurrence of cyst infection after kidney transplantation
Cyst infection was significantly associated with graft loss
Summary
We conducted a single-center retrospective cohort study of patients with ADPKD with renal allografts between January 1, 2009, and October 31, 2020. We conducted a single-center study on all consecutive adult patients transplanted or retransplanted at Nantes. University Hospital between January 1, 2009, and October 31, 2020, for whom the primary renal disease was ADPKD. Patients with primary nonfunctioning allograft were excluded from the study. All data were extracted from the French multicenter, observational, and prospective. The infectious episodes were recorded prospectively, each medical records of the patients included in the study were retrospectively reviewed to identify patient with history of cyst infection before transplantation and during the post-transplantation period. Clinical, biological, imaging, and cyst infection parameters and cyst infection outcomes were collected
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
