Incidence rate of symptomatic venous thromboembolic disease in patients from a medical care program in Buenos Aires, Argentina: a prospective cohort

Fernando Vázquez,María Posadas-Martínez,Jimena Vicens,Diego Giunta,Fernán González Bernaldo De Quirós

doi:10.1186/1477-9560-11-16

Fernando Vázquez, María Posadas-Martínez + Show 3 more

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https://doi.org/10.1186/1477-9560-11-16

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Journal: Thrombosis journal	Publication Date: Jan 1, 2013
Citations: 53	License type: cc-by

Affiliation: Hospital Italiano de Buenos Aires

Abstract

BackgroundThe incidence of venous thromboembolic disease (VTED) is estimated to be, on average, 1–2 cases per 1,000 individuals per year worldwide. There are few data concerning the incidence rate (IR) of VTED in the Argentinean population at large.Our aim was to estimate the IR of VTED at the Italian Hospital Medical Care Program (IHMCP) in Buenos Aires, the most populous city in Argentina.MethodsThis prospective cohort study evaluated all consecutive incident cases of pulmonary thromboembolism (PTE) and deep vein thrombosis (DVT) confirmed in patients over the age of 17 who were members of the IHMCP from June 2006 to May 2012. Any patient who had an initial confirmed VTED episode and was a member of the IHMCP at the time of diagnosis was considered an incident case.ResultsThere were 1,138 cases of VTED for 687,871 person-years of follow-up. The crude IR of VTED was 1.65 (95% CI: 1.56 to 1.75) per 1,000 person-years. The highest IR was found in subjects >80 years old (5.92 per 1,000 person years; 95% CI: 5.41 to 6.49).The IRs adjusted to the population of the city of Buenos Aires were 0.90 (95% CI: 0.84 to 0.95) for VTED, 0.71 (95% CI: 0.66 to 0.76) for DVT, and 0.34 (95% CI: 0.31 to 0.37) for PTE.ConclusionsVTED is a common health problem with a high IR in members of the IHMCP, especially the elderly. This is the first paper to report prospectively the cumulative incidence of VTED in Latin America.

Highlights

The incidence of venous thromboembolic disease (VTED) is estimated to be, on average, 1–2 cases per 1,000 individuals per year worldwide
Females accounted for 62.56% (712) of VTED cases, 61.38% (550) of deep vein thrombosis (DVT) cases, and 65% (286) of pulmonary thromboembolism (PTE) cases
The crude incidence rate (IR) per 1,000 person-years was 1.65 for VTED, 1.30 for DVT, and 0.64 for PTE (Table 3 and Figure 1)

Summary

Introduction

The incidence of venous thromboembolic disease (VTED) is estimated to be, on average, 1–2 cases per 1,000 individuals per year worldwide. There are few data concerning the incidence rate (IR) of VTED in the Argentinean population at large. Our aim was to estimate the IR of VTED at the Italian Hospital Medical Care Program (IHMCP) in Buenos Aires, the most populous city in Argentina. Venous thromboembolic disease (VTED) is the most common preventable cause of death among hospital patients [1]. While VTED can affect patients of any age, it is reported that its frequency increases in older individuals [2]. The most common manifestations of VTED include pulmonary thromboembolism (PTE) and deep vein thrombosis (DVT) of the lower limbs [1,3-6]. The incidence rate for the initial episode of VTED is between 0.71 and 1.17 cases per 1,000 persons of the Caucasian population [2,13-19]. The incidence variability depends on the data source (detection through surveys or via various diagnostic studies), the record type, symptomatic or asymptomatic events, the inclusion of only primary events or recurrences, and study design

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