Abstract
IN the past few years a new type of metabolic lesion of the red cell has been elucidated. It was found that sensitivity to the haemolytic action of the 8-aminoquinoline primaquine and many other compounds was due to an intrinsic defect of the red cell1. This defect can be demonstrated in vitro by: (1) incubating the red cells with a solution of acetylphenylhydrazine and observing the pattern of Heinz body formation2, and (2) incubating the red cells with acetylphenylhydrazine or a number of other substances and measuring the level of reduced glutathione after an incubation period of 2 hr. (the glutathione stability test)3, or (3) measuring the activity of the enzyme glucose-6-phosphate dehydrogenase in the red cells4.
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