Abstract
Introduction: The objectives of this study were to study the incidence and risk factors of retinopathy of prematurity (ROP) among preterm low birth weight babies and its association with oxygen therapy.Material and Methods: During one year study period, 50 neonates, who had fulfilled the inclusion criteria (born at gestational age ≤ 35 wks), were included in the present study. They were examined by indirect ophthalmoscopy by an ophthalmologist in NICU or ophthalmology outdoor. Staging of ROP was done according to the International classification. Data obtained from this study were entered in Microsoft Excel and subsequently analysed in SPSS version 20.0.Results: Among study population, 12 neonates (24%) showed evidence of retinopathy of prematurity, and Stage 2 ROP was most common (41.7%) within this group. Those neonates who had born ≤28 wks gestational age, showed more incidence (75%) of ROP. There was significant association between ROP and prematurity, low birth weight, mechanical ventilation, duration and concentration of oxygen therapy.Conclusion: Apart from prematurity and low birth weight, oxygen therapy also carries significant risk for ROP. Thus, judicious use of oxygen in premature babies can reduce incidence of ROP significantly.J Nepal Paediatr Soc 2015;35(3):247-252
Highlights
The objectives of this study were to study the incidence and risk factors of retinopathy of prematurity (ROP) among preterm low birth weight babies and its association with oxygen therapy
24% had some evidence of ROP and 76% had no ROP detected
Several report subsequently suggested that an inspired oxygen concentra on less than 40% was unlikely to lead to ROP11,12
Summary
The objectives of this study were to study the incidence and risk factors of retinopathy of prematurity (ROP) among preterm low birth weight babies and its association with oxygen therapy. Material and Methods: During one year study period, 50 neonates, who had fulfilled the inclusion criteria (born at gestational age ≤ 35 wks), were included in the present study. Results: Among study population, 12 neonates (24%) showed evidence of retinopathy of prematurity, and Stage 2 ROP was most common (41.7%) within this group Those neonates who had born ≤28 wks gestational age, showed more incidence (75%) of ROP. Choroidal vessels supply the outer half of the re na by diffusion They are more permeable, and have a high venous PaO2, lack the ability of autoregula on in response to hyperoxia. A meta-analysis by Askie and Hendersonsmart[4] of 5 randomized control trials conducted in preterm infants in which ambient O2 concentra on were targeted to achieve either a lower or higher blood O2 range was unable to determine the op mal
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