Abstract
BackgroundHuman immunodeficiency virus (HIV) infection is associated with an increased risk for human herpes viruses (HHVs) and their related diseases and they frequently cause disease deterioration and therapeutic failures. Methods for limiting the transmission of HHVs require a better understanding of the incidence and infectivity of oral HHVs in HIV-infected patients. This study was designed to determine the seroprevalence of human herpes viruses (CMV, HSV 2, EBV-1, VZV) antibodies and to evaluate their association with age, sex as well as other demographic and behavioral factors.ResultsA study of 200 HIV positive patients from Eastern India attending the Calcutta Medical College Hospital, Kolkata, West Bengal, Apex Clinic, Calcutta Medical College Hospital and ART Center, School of Tropical Medicine, Kolkata, West Bengal was done. Serum samples were screened for antibodies to the respective viruses using the indirect ELISA in triplicates.CytoMegalo virus (CMV), Herpes Simplex virus type 2 (HSV-2), Varicella Zoster virus (VZV), and Epstein Barr virus (EBV-1) were detected in 49%, 47%, 32.5%, and 26% respectively.ConclusionThis study has contributed baseline data and provided insights in viral OI and HIV co-infection in Eastern India. This would undoubtedly serve as a basis for further studies on this topic.
Highlights
Human immunodeficiency virus (HIV) infection is associated with an increased risk for human herpes viruses (HHVs) and their related diseases and they frequently cause disease deterioration and therapeutic failures
Cytomegalovirus (CMV), Herpes Simplex virus 1 & 2 (HSV-1 & 2), Vericella Zoster virus (VZV), Epstein Barr virus
Study site and patient recruitment In our study, we reviewed 200 HIV/acquired immunodeficiency syndrome (AIDS) patients, admitted between January 2006 to November 2008 at Calcutta Medical College Hospital, Kolkata, West Bengal, Apex Clinic, Calcutta Medical College Hospital- a referral center for patients of HIV infection or AIDS, and ART Center, School of Tropical Medicine, for the detection of viral opportunistic infections
Summary
Human immunodeficiency virus (HIV) infection is associated with an increased risk for human herpes viruses (HHVs) and their related diseases and they frequently cause disease deterioration and therapeutic failures. Cytomegalovirus (CMV), Herpes Simplex virus 1 & 2 (HSV-1 & 2), Vericella Zoster virus (VZV), Epstein Barr virus These herpes viruses are usually acquired in childhood or young adulthood, establish a state of asymptomatic latency, and may eventually reactivate to give clinical disease later in life or following an HIV induced decline in cell-mediated immune control. Retinitis is most frequent clinical manifestation of CMV though other manifestations like gastrointestinal disease, encephalitis and pneumonia may occur
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