Abstract
The Manchester Children's Tumour Registry data for the period 1954-1977 have been analysed. The overall incidence of malignant disease in children aged 0-14 years in the north-west of England is estimated to be 100 per million person-years. The most common disease group is leukaemia, which forms about one third of the total number of cases. Among solid tumours, by far the most common presenting site is the central nervous system, representing nearly a quarter of all neoplasms. Wilms' tumour, neuroblastoma and soft-tissue sarcomas comprise approximately 5%, 6.5% and 6% respectively of the total. The tumours most frequently seen in adults (e.g. carcinoma of colon, lung and breast) are extremely rare in childhood. A significant excess of males was seen in acute lymphoid leukaemia, non-Hodgkin's lymphoma, Hodgkin's disease, medulloblastoma and hepatoblastoma. A female excess was found among germ-cell tumours. During the study period significant increases in incidence were seen among acute lymphoid leukaemia and epithelial tumours, and an increase in germ cell tumours approached significance.
Highlights
Summary.-The Manchester Children's Tumour Registry data for the period 19541977 have been analysed
A significant excess of males was seen in acute lymphoid leukaemia, non
During the study period significant increases in incidence were seen among acute lymphoid leukaemia and epithelial tumours, and an increase in germ cell tumours approached significance
Summary
Summary.-The Manchester Children's Tumour Registry data for the period 19541977 have been analysed. The most common disease group is leukaemia, which forms about one third of the total number of cases. During the study period significant increases in incidence were seen among acute lymphoid leukaemia and epithelial tumours, and an increase in germ cell tumours approached significance. IT HAS BEEN STATED that in order to determine the incidence of malignant disease in childhood by histological type, a population-based study with complete or unbiased ascertainment of cases and special pathological review is required (Young & Miller, 1975). In a recent report (Draper et al, 1980) mortality and survival as well as incidence for the period 1954 to 1973, as estimated by the MCTR, are described for broad tumour categories, and are compared with the available national data. The purpose of the present paper is to provide incidence figures, using a more detailed histological breakdown for a longer series of cases (1954-1977) and to report trends in incidence with time for various tumour groups
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