Incidence of Ischemic Stroke in US Veterans Living with Spinal Cord Injury: Preliminary Data (S3.005)

Abstract

<h3>Objective:</h3> In this preliminary study, we estimate the 4-year incidence of ischemic stroke and associated risk factors in United States (US) Veterans living with spinal cord injuries and disorders (SCI/D). <h3>Background:</h3> People with SCI/D have been reported to have an elevated risk of ischemic stroke, based on a study in the population of Taiwan [Wu et al, Neurology. 2012;78:1051–1057]. This prior study reported a cumulative incidence rate of ischemic stroke of 1.9% over 4 years subsequent to SCI, vs 0.6% in matched non-injured controls. <h3>Design/Methods:</h3> We used Department of Veterans Affairs (VA) administrative databases to examine the incidence of ischemic stroke between fiscal years 2018–2021. Veterans living with strokes were identified using ICD-9 or 10 codes for cerebral infarction or sequelae of cerebral infarction. Veterans with diagnoses of ischemic strokes or sequelae during 2013–2017 were excluded. Statistical analyses included frequencies and multiple regression models. <h3>Results:</h3> From FY 2018–2021, 394 of 12,547 Veterans living with SCI had a newly-recorded ischemic stroke, reflecting a 4-year incidence of 3.14%, and an average annual incidence of 0.79%. Compared to Veterans with a D injury classification by the American Spinal Injury Association (ASIA) Impairment Scale, Veterans with high tetraplegia had a higher likelihood of ischemic stroke (IRR=1.91, 95% CI: 1.37 – 2.67). Compared to Veterans with traumatic SCI, Veterans with non-traumatic SCI/D also had a higher likelihood of ischemic stroke (IRR = 1.43, 95% CI: 1.13 – 1.80). <h3>Conclusions:</h3> US Veterans with SCI/D have a higher incidence of ischemic stroke than that reported for the Taiwanese population with SCI. Tetraplegia and a non-traumatic injury etiology seem to be SCI-centric risk factors. Further study will include comparison of stroke incidence to that of age- and sex-matched US Veterans without SCI. <b>Disclosure:</b> The institution of Dr. Willenberg has received research support from Dept of Veterans Affairs. The institution of Dr. Smith has received research support from Dept of Veterans Affairs . Kevin Stroupe has received research support from Department of Veterans Affairs. Dr. Sippel has nothing to disclose. Zhiping Huo has nothing to disclose. Dr. Sabharwal has received publishing royalties from a publication relating to health care.