Abstract
Objective: To determine the prevalence of hypertension in hospitalized patients with asthma who were treated with beta-2 agonists. To evaluate the correlation between the duration of the use of beta-2 agonist with the incidence of hypertension.Methods: This research is a descriptive epidemiological, observational cross-sectional and retrospective study design. The study population was all adult asthma patients (age ≥ 25) without a concomitant diseases such as hypertension or metabolic syndrome treated with β2 agonists as a bronchodilator and underwent hospitalized in January 2015-December 2015 (n=108). Patient data were collected from the medical record. Data were analyzed using univariate and bivariate to count the number of occurrences of hypertension and recognizing the correlation between the duration of the use of β2 agonists with hypertension event.Results: The incidence of hypertension in patients with asthma who were treated with beta-2 agonists are 50, 93% at the stage of pre-hypertension (120 mm Hg/80 mm Hg) and 25, 9% in stage I hypertension (140 mmHg/90 mmHg). Body weight and duration of therapy with a β2 agonist positively correlated with the incidence of hypertension with a correlation coefficient (r) 0.231 and 0.386 respectively.Conclusion: In this study, duration of therapy with a β2 agonist in asthma patients positively correlated with the incidence of hypertension.
Highlights
Asthma is a chronic inflammatory disorder of the airways
Asthma can be triggered by various factors such as allergic responses, respiratory infections, excessive physical exercise, irritation of the respiratory tract and the use of anti-inflammatory drugs that can cause airway obstruction, and bronchoconstriction [1]
The study population was all adult asthma patients without a concomitant disease such as hypertension or metabolic syndrome treated with β2 agonist as a bronchodilator and underwent hospitalized in January 2015-December 2015 (n=108)
Summary
Asthma is a chronic inflammatory disorder of the airways. Asthma is a very common disease that involves complex interactions between environmental factors, airway obstruction, bronchial hyper responsive, and inflammation. The main picture dominant cause clinical symptoms is smooth muscle contraction and inflammation that cause shortness of breath, coughing, wheezing or chest tightness. Asthma can be triggered by various factors such as allergic responses, respiratory infections, excessive physical exercise, irritation of the respiratory tract and the use of anti-inflammatory drugs that can cause airway obstruction, and bronchoconstriction [1]. Eosinophils and T-lymphocytes are important mediator in causing asthma. Inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness and coughing, at night or early morning. Symptoms of respiratory tract obstruction may be reversible spontaneously or with treatment [2]
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