Incidence of hepatocellular carcinoma in Texas Latinos, 1995-2010: an update.

Lucina Suarez,Edgar Munoz,Rebecca T Adeigbe,Amelie G Ramirez,Alan E C Holden,Anand S Mehta

doi:10.1371/journal.pone.0099365

Lucina Suarez, Edgar Munoz + Show 4 more

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https://doi.org/10.1371/journal.pone.0099365

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Abstract

BackgroundA previous study showed Hepatocellular Carcinoma (HCC) rates to be higher among Latinos in Texas and highest among South Texas Latinos compared to other non-Hispanic whites (NHW) and other Latinos in the United States (U.S.). We used more recent data to assess trends in HCC among Texas Latinos and to reassess the elevated HCC incidence rate in Texas Latinos.MethodsWe used data from the U.S. SEER Program and the Texas Cancer Registry to calculate annual and 3-year moving average age-specific and age-adjusted HCC incidence rates, annual percent changes (APCs), and their corresponding 95% confidence intervals for Latinos and NHW in the U.S., Texas and South Texas.ResultsTexas Latino male and female incidence rates were 3.1 and 4.0 times higher than their NHW counterparts in SEER regions. Latino males and females in South Texas had the highest rates of HCC incidence overall; rate ratios were 3.6 and 4.2 among South Texas Latino males and females compared to SEER NHW counterparts. There are statistically significant increases in HCC incidence rates in all groups (Texas and South Texas Latinos and NHW groups) and across all age groups. The elevated HCC rates in Texas Latinos are consistent over the 1995–2010 period.ConclusionsThe incidence of HCC among Latinos in South Texas remains higher than elsewhere in the U.S. and warrants closer investigation of potential risk factors related to prevailing conditions unique to the population including higher obesity and diabetes rates, environmental, cultural and socioeconomic factors and possibly genetic predisposition.

Highlights

Hepatocellular Carcinoma (HCC) incidence rates continue to increase globally and in the United States (U.S.); incidence rates have historically been higher in Asia and West and Central Africa surveillance trends indicate that HCC age-adjusted incidence rates have almost tripled in the U.S over the past 20 years [1,2]
We have previously reported on the much higher HCC incidence rates of Latinos living in Texas and South Texas
We examined the trends in HCC incidence for Latinos in South Texas and Texas and reassessed the elevated relative risks among Texas Latinos using more recent data through 2010

Summary

Introduction

Hepatocellular Carcinoma (HCC) incidence rates continue to increase globally and in the United States (U.S.); incidence rates have historically been higher in Asia and West and Central Africa surveillance trends indicate that HCC age-adjusted incidence rates have almost tripled in the U.S over the past 20 years [1,2]. For the period 1995–2006, HCC age adjusted incidence rates in South Texas Latinos were 10.6/100,000 compared to 9.5 and 7.5 for Latino in the rest of Texas and the U.S and 3.1 and 2.9 among NHW in Texas and the U.S [8]. A previous study showed Hepatocellular Carcinoma (HCC) rates to be higher among Latinos in Texas and highest among South Texas Latinos compared to other non-Hispanic whites (NHW) and other Latinos in the United States (U.S.).

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