Abstract
Background: Chronic cholecystitis due to cholelithiasis is one of the most common hepatobiliary surgical disorders. Bacteria are found in high concentration in bile and stone. Helicobacter hepaticus is a gram negative, micro-aerobic bacterium, curved to spiral in shape which shows positivity with urease, catalase and oxidase. Bacterial infection may be one of the causes for the pathogenesis of gallstone formation as most gallstones are colonized by a bacterial biofilm. Materials and Methods: This was a retrospective study done in the Department of Pathology, Kathmandu Medical College for a one year period, between June 2007 and July 2008. A total of 277 cases were included in the study. Results: Amongst the 277 cases, 270 cases (97.4%) were diagnosed as chronic cholecystitis and 7 cases (2.5%) were diagnosed as gallbladder carcinoma. All the cases diagnosed as gallbladder carcinoma was of adenocarcinoma except a single case of adenosquamous carcinoma. Fifty three out of the 277 cases (19.13%) showed positivity in Warthin Starry Silver stain. Out of the 7 cases diagnosed as gallbladder carcinoma, 5 cases were found to be positive Warthin Starry Silver stain. Conclusion: The role of Helicobacter hepaticus infection as a nidus for formation of gallstone that ultimately leads to malignancy is controversial and its dominant role in the pathogenesis of carcinoma is yet to be determined. Keywords: Gallbladder carcinoma; Helicobacter hepaticus; Warthin Starry Silver stain. DOI: http://dx.doi.org/10.3126/jpn.v1i2.5406 JPN 2011; 1(2): 122-125
Highlights
Chronic cholecystitis due to cholelithiasis is one of the most common hepatobiliary surgical disorders
It is difficult to say whether bacterial infection of the bile occurs before stone formation or stone formation occurs after bacterial infection
Amongst the 277 cases, 270 cases (97.4%) were diagnosed as chronic cholecystitis and 7 cases (2.5%) were diagnosed as gallbladder carcinoma
Summary
Chronic cholecystitis due to cholelithiasis is one of the most common hepatobiliary surgical disorders. The incidence of cholelithiasis is 4 times higher in women than in men with high prevalence among the age group of 30-40 years. Correspondence: It is difficult to say whether bacterial infection of the bile occurs before stone formation or stone formation occurs after bacterial infection. Pylori) in 1982 by Marshall and Warren, more than 25 additional Helicobacter species have been isolated. Helicobacter hepaticus (H. hepaticus) was discovered in 1992 at the National cancer institute- Fredrick Cancer Research and Development Centre and first isolated from a colony of mice, a low liver tumor incidence mouse strain with a. Bacteria are found in high concentration in bile and stone. Bacterial infection may be one of the causes for the pathogenesis of gallstone formation as most gallstones are colonized by a bacterial biofilm
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