Incidence of head and neck cancer among first-generation immigrants and their children in Finland

Abstract

IntroductionLimited data exist regarding head and neck cancer (HNC) burden among immigrants who may have distinct characteristics, and hence different incidence rates from the general population. Variations in behavioral habits, cultural lifestyle, or diet may cause variations across different subgroups.MethodsThe whole immigrant population of Finnish residents born abroad, and their children were retrieved for the years 1970–2017. First-generation immigrants are defined as individuals born abroad, excluding their children (even if born abroad). The study comprised 0.5 million first-generation immigrants and 0.3 million children, contributing to 6 million and 5 million person-years of follow-up, respectively. Standardized incidence ratios (SIR) and excess absolute risk (EAR) per 100,000 person-years at risk were calculated to quantify the risk of HNC among immigrants relative to the general Finnish population.ResultsThe overall risk of any HNC was not increased among first-generation male immigrants (SIR 1.00, 95% CI: 0.88–1.15), but significantly elevated for cancer of the pharynx (SIR 1.56, 95% CI: 1.22–1.95), and larynx (SIR 1.38, 95% CI: 1.02–1.83) and decreased for lip (SIR 0.38, 95% CI: 0.20–0.67). The increased risk of pharyngeal cancer was highest among male immigrants from Asia Pacific (SIR 4.21, 95% CI: 2.02–7.75). First-generation immigrant women had a significantly reduced risk of any HNC (SIR 0.45, 95% CI: 0.37–0.55), which remained even after stratification by site. We observed no increased risk of any HNC among the children of first-generation immigrants.ConclusionHealthcare professionals need to recognize the groups at higher HNC risk. Efforts to address the main etiological risk factors, such as smoking, are needed among the selected immigrant populations, that haven’t yet reached similar decreasing trends, as in for example smoking, as the main population.NOVELTY AND IMPACTCurrently, globally, over 280 million people live outside their country of birth. Limited data exist regarding head and neck cancer (HNC) burden among immigrants who may have distinct characteristics and hence different incidence rates from the general population. Immigrant studies can provide novel data by shedding light on risk alterations and the pace of acculturation of different populations.