Abstract
BackgroundThis is the first report of the incidence and causes of end-stage renal disease (ESRD) of the Turkish-Cypriot population in Northern Cyprus.MethodsData were collected over eight consecutive years (2004–2011) from all those starting renal replacement therapy (RRT) in this population. Crude and age-standardised incidence at 90 days was calculated and comparisons made with other national registries. We collected DNA from the entire prevalent population. As an initial experiment we looked for two genetic causes of ESRD that have been reported in Greek Cypriots.ResultsCrude and age-standardised incidence at 90 days was 234 and 327 per million population (pmp) per year, respectively. The mean age was 63, and 62% were male. The age-adjusted prevalence of RRT in Turkish-Cypriots was 1543 pmp on 01/01/2011. The incidence of RRT is higher than other countries reporting to the European Renal Association – European Dialysis and Transplant Association, with the exception of Turkey. Diabetes is a major cause of ESRD in those under 65, accounting for 36% of incident cases followed by 30% with uncertain aetiology. 18% of the incident population had a family history of ESRD. We identified two families with thin basement membrane nephropathy caused by a mutation in COL4A3, but no new cases of CFHR5 nephropathy.ConclusionsThis study provides the first estimate of RRT incidence in the Turkish-Cypriot population, describes the contribution of different underlying diagnoses to ESRD, and provides a basis for healthcare policy planning.
Highlights
In recent years end-stage renal disease (ESRD) has become an increasing public health challenge for high and middle income countries, with an associated escalation of the cost of providing renal replacement therapy (RRT) [1,2,3,4]
More males than females started RRT (139 vs 86), but the age distribution was similar between the sexes (Table 1). 18.2% of the incident population had a first or second degree relative with ESRD, and this rose to 27% in those with ESRD due to uncertain aetiology
Tetra primer PCR identified two individuals on RRT with the G871C mutation in COL4A3 previously reported in Greek-Cypriot pedigrees [17]
Summary
In recent years end-stage renal disease (ESRD) has become an increasing public health challenge for high and middle income countries, with an associated escalation of the cost of providing renal replacement therapy (RRT) [1,2,3,4]. The collection of accurate epidemiological data is of great importance for healthcare policy planning [1,2,3] This is especially true for places where the infrastructure delivering RRT is improving, such as the island of Cyprus. ESRD attributed to type 2 diabetes and hypertension continues to rise throughout the world, and this is increasingly true for countries such as Cyprus [2,9,10,11]. This is the first report of the incidence and causes of end-stage renal disease (ESRD) of the Turkish-Cypriot population in Northern Cyprus
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