Abstract
The frequency of development of ventricular ectopic beats was studied at different basic frequencies under conditions which facilitate the induction of ectopic beats and fibrillation in the ventricle. Ectopic beats were more frequently induced by coronary occlusion, sudden elevation of the aortic pressure, and hypothermia when the basic frequency was low. The average time of onset of ectopic beats after the start of coronary occlusion decreased with a decrease in basic frequency. Ectopic beats developed more frequently after the second stimulated responses at slow rates of paired-pulse stimulation. The stimulus strength required to induce such ectopic beats was much lower at slower frequencies of paired-pulse stimulation. The results emphasize the importance of selection of an optimum rate of stimulation.
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