Incidence of early-onset multiple myeloma among families with endometrial carcinoma.

Abstract

1583 Background: In a recent study, multiple myeloma (MM) was found in excess and at an earlier age in first-degree relatives of endometrial carcinoma (EC) patients. We reviewed the Creighton Hereditary Cancer Center experience of MM and EC pedigrees. Methods: After identifying all probands with MM or EC we examined pedigrees with coincident diagnoses of EC and MM. The diagnosis of EC or MM was primarily verified by review of pathology reports or death certificates. Summary statistics including mean and median ages at diagnosis were calculated. Statistical analysis was used to investigate the null hypothesis of no significant age difference at diagnosis of MM and EC in families with MM, EC, and EC/MM. Results: We could not find a single individual proband with both MM and EC in our database. We found 696 individuals with EC and 126 cases of MM in 586 families. We found 26 cases of EC and 26 cases of MM in 20 families in which both cancers were reported. In contrast to the prior study, there was no significant reduction in age at diagnosis of MM in pedigrees with EC. In fact, in our cohort, there was a trend for later onset of EC in families with coincident EC/MM, another argument against a hereditary predisposition. Conclusions: We found no increase in incidence of early onset myeloma in families with EC. Our data does not support an EC and MM correlation (Zighelboim et al. Gynecol Oncol 2007;105:390–4). Families with either MM or EC Families with both MM and EC Test p value Multiple Mean 65.3 64.69 Two-sample pooled t-test 0.82 myeloma Median 65 65.5 Mann-Whitney-Wilcoxon test 0.7676 Endometrial Mean 51.68 57.92 Two-sample pooled t-test 0.0191 carcinoma Median 51 52 Mann-Whitney-Wilcoxon test 0.0452 No significant financial relationships to disclose.