Incidence of Differentiated Thyroid Carcinoma in Multinodular Goitre Patients in Western UP

Abstract

Background The prevalence of multinodular goitre in all over the world is high, commonly in developing countries. Incidence of differentiated thyroid carcinoma among patients with multinodular goitre is increased in recent literature. Aim of Study To determine the incidence rate of differentiated thyroid carcinoma among patients with multinodular goitre. Patients and Method This study is a cross sectional study carried out in Surgical Ward of Saraswati Institute Of Medical Sciences,Hapur, during the period from September 2016 to July 2017 on convenient sample of 60 patients with multinodular goitre. Clinical history and examination, fine needle aspiration and postoperative histopathology examination was done to confirm the diagnosis. Results Mean age of patients was 43.9 years, with 5 males and 55 females. Fine needle aspiration test showed that 13 (21.7%) multinodular goitre patients had differentiated thyroid carcinoma, while 47 (78.3%) patients had benign goitre. The histopathology of multinodular goitre patients revealed that 41.7% of them had colloid goitre, 16.7% of them had micro-papillary carcinoma and 38.3% of them had follicular adenoma. Differentiated thyroid carcinoma among multinodular goitre patients was significantly associated with smoking and exposure to ionizing radiation. Conclusions The incidence of differentiated thyroid carcinoma among multinodular goitre patients is high.