Incidence of deep infection, union and malunion for open diaphyseal femoral shaft fractures treated with IM nailing: A systematic review

Abstract

Backgroundand purpose: We have undertaken a systematic review to evaluate the clinical results of intramedullary nailing (IMN) for open diaphyseal femoral fractures on the rates of union, delayed union, malunion, superficial and deep infection and bone grafting. MethodsWe searched the electronic databases of EMBASE, MEDLINE, from their inception until December 1st, 2017 with no language restrictions. The reference lists of all included articles and relevant reviews were also examined for potentially eligible studies. Hand search using electronic database of recent major orthopaedic journals was also carried. Two reviewers working independently extracted study characteristics and data to estimate the diagnostic odds ratio and 95% confidence interval for each result. ResultsSeventeen studies were eligible. Pooled estimate of effect size for union rate was 97% (95% CI: 94–99%). Deep infection rate was 6% (95% CI: 3–9.3%) and more prominent in Gustilo type III injuries; superficial infection was 5.6% (95% CI: 3–9.3%). Delayed union rate 3% (95% CI: 1–5.6%) while, malunion rate was 8.4% (95% CI: 5.7–11.6%). The need for bone grafting ranged from 0 to 9%. ConclusionsIMN remains the treatment of choice for open femoral diaphyseal fractures with very good union rates. Gustilo grade III injuries demonstrate a distinct higher deep infection rate and strict adherence to established surgical debridement and fixation protocols is advocated. The need for bone grafting can be as high as 9% and patients should be made aware of the possibility of requiring this additional procedure.