Incidence of Cryptogenic Stroke in Covid-19 Patients

Abstract

Introduction The risk of ischemic stroke during COVID-19 is approximately 5% reported by WHO. Hemorrhagic strokes are less common compared to ischemic ones, but few cases have been reported. The strokes are called a cryptogenic strokes which means an unknown origin. Diagnostic investigations were incomplete in patients with COVID-19 leading to a high rate of cryptogenic stroke. Materials and Methods It is a prospective observational study conducted at a single centered hospital in Hanamkonda the data was collected from January 2020 to April 2020 and all Parameters were expressed as Mean ± Standard Deviation (SD). Data analysis was performed using MS Excel and Graphpad Prism (9.0 version). A One-Way ANOVA (Analysis of variance) followed by Dunnett’s Multiple Comparison test was done to assess the significant difference between visit 1and visit 3 cryptogenic parameters. A p-value <0.0001 was considered significant. Results There were significant changes observed from visit 1 to visit 3 in evaluating the parameters and treatment of coagulation and inflammation. Conclusion The risk of cryptogenic stroke in COVID-19 infected patients was assessed by considering parameters such as TLC, CRP, LDH, RBS, FERRITIN, D-DIMER, IL-6 and it can be concluded that the evaluation of the above parameters is to be evaluated in every patient irrespective of comorbidities, age, and anti-coagulants, anti-diabeticandanti-inflammatoryagentswillplayasubstantialroleinthe management of cryptogenic stroke in COVID-19.