Abstract
More new diagnosed syphilis cases were reported in china, the incidence and relevant factors of asymptomatic neurosyphilis (ANS) in serofast syphilis patients were unclear. Clinical and laboratory data of 402 Human Immunodeficiency Virus (HIV) negative, serofast syphilis patients, who underwent lumbar puncture at the Peking University Ditan Teaching Hospital between September 2008 and August 2016, were collected. Incidence of ANS was verified and the relevant factors were further analyzed. According to the ANS criteria, 139 (34.6%) patients had ANS. Of these, 40 (28.8%) had reactive cerebrospinal fluid (CSF), rapid plasma reagin (RPR) positive, 115 (82.7%) had CSF white blood cell (WBC) count > 5 × 106/L, 28 (20.1%) had CSF protein concentration > 45 mg/dL (without other neurological diseases). Patients aged 51–60 years, of non-Han ethnicity, with serum RPR titer 1:32 and ≥ 1:64 were 2.28-fold, 9.11-fold, 5.12-fold and 5.69-fold, respectively, more likely to have ANS. The incidence of ANS was 34.6% among Chinese serofast syphilis patients. Age, ethnicity and serum RPR titer were associated with high risk of ANS.
Highlights
The incidence of syphilis is rapidly increasing in China[1]
Studies have documented the incidence of neurosyphilis in different stages of syphilis or among various populations (HIV-negative, Human Immunodeficiency Virus (HIV)-positive), and relevant factors of neurosyphilis among HIV-negative and/or HIV-positive syphilis patients[6,10,11]
We examined the incidence of asymptomatic neurosyphilis (ANS) in asymptomatic syphilis patients with serofast state
Summary
The incidence of syphilis is rapidly increasing in China[1]. Syphilis is a systemic and infectious disease caused by Treponema pallidum, which can disseminate to any organ shortly after infection. Neurosyphilis can occur at any stage of syphilis, after invasion of the central nervous system by Treponema pallidum, and its most common form is asymptomatic neurosyphilis (ANS)[2]. In China, the incidence of serofast state was 34.4%, but the rate of ANS in the asymptomatic serofast syphilis patients remains unknown[9,10]. This study explored the incidence of ANS and relevant factors through analysis of clinical and laboratory data of 402 asymptomatic serofast syphilis patients
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