Abstract
Background: Adverse drug events (ADE) are a major health and economic problem. There is no information regarding incidence of ADE in Cabo Verde and trigger tools are an efficient active data collection method. Objective: To develop the first PV study in Cabo Verde and characterize ADE in a hospital. Method: This is a retrospective study of chart review using the Global Trigger Tool (GTT) developed by the Institute for Healthcare Improvement (IHI). The simple random sample of medical records for patients discharged from October 2012 to March 2013 and from October 2013 to March 2014. Hospitalization for less than 48 h, time spent in intensive care unit and medical records with no drug administration records were excluded. Results: A total of 383 medical records data were collected. The average age of patients was 37 and 40 years, 62.6% and 59.8% of the total were females. A total 287 triggers were identified, 184 and 103 triggers for first and second period, respectively. For the first period, a total of 105 ADE were identified in 54 patients with the incidence of 28.4% patient presenting ADE and a rate of 54% ADEs per 100 patients, in the second period, a total of 77 ADE were identified in 38 patients with the incidence of 19.6% and a rate of 38% ADE per 100 patients. Drugs more often associated with an ADE were ceftriaxone, furosemide, metronidazole and ranitidine. Conclusion: The trigger tool had a good performance detecting ADE. About ¼ of the hospitalized patients in hospital showed adverse events. Further studies are needed using prospective method and extended period.
Highlights
Adverse drug events (ADE) are a major health and economic problem
One of the four countries assessed by WHO as having installed pharmacovigilance capacity [4], identified that 4.5% of patients were hospitalized with ADE, 1.6% were hospitalized due to ADE and that ADE occurs during hospitalization in 49.5% of patients
All results will be presented for the first period with 190 medical records from October 2012 to March 2013 and for the second period with 193 medical records from October 2013 to March 2014
Summary
Adverse drug events (ADE) are a major health and economic problem. Adverse drug events (ADE) are frequent, a leading cause of morbidity, mortality and costly [1]. It is estimated that the overall incidence of ADE, including both those that cause hospitalization and those that occur during hospitalization, is 15.1%, and in this range 6.7% are severe [2]. Another systematic review of 29 studies found between 1.7 and 51.8 events per 100 hospitalizations [3]. In the sub-Saharan African region where Cabo Verde is located, there are few pharmacovigilance (PV) studies. The ADE were found to be an important morbidity factor for both community and hospital and is associated with the most widely used drugs [5]
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