INCIDENCE, CLINICAL PROFILE AND OUTCOME OF PATIENTS OF ACUTE CORONARY SYNDROME PRESENTING WITH VITAMIN D DEFICIENCY: A STUDY FROM NORTH INDIA

Abstract

Background: Vitamin D insufficiency is believed to affect 50% of the population worldwide and the deficiency of this important vitamin has become a key health concern across the world today. Several cross-sectional and prospective studies have shown an association between low Vitamin D status and CVD and associated mortality. Aims and objectives: To study the incidence, clinical profile and major adverse coronary events in patients of acute coronary syndrome presenting with low vitamin D level and compare with patients of acute coronary syndrome with normal vitamin D level during hospital stay and 6 months post-discharge in a tertiary care hospital. Patients and Methods: A total of 117 patients with acute coronary syndrome admitted to ICCU were enrolled for the study. Vitamin D level was estimated in these patients and their family members/relative of the comparable age group for control. The incidence, clinical profile and major adverse coronary events (MACE) were studied during 5 days of their hospital stay and at 1, 3 and 6 months post-discharge. Results: We found high prevalence of vitamin D deficiency in patients with ACS as well as in the general population (controls). However, the incidence was much higher in the study population as compared to controls. We also found that the occurrence of MACE was much higher in the low vitamin D group, compared to the normal vitamin D group. Conclusion: Low vitamin D level in patients with ACS is associated with poorer outcomes (higher incidence of MACE) compared to patients having normal vitamin D levels.