Abstract
In a series of 185 patients (median age 7 years) of acute lymphoblastic leukaemia (ALL) from India, the overall incidence of ALL-1 gene rearrangement using the Southern blot technique was 11.4% (21/185). The incidence amongst the infants (age ≤1 year, 70%) was significantly higher when compared to patients >1–≤10 years (7.4%, P=0.00001) as well as >10 years old (9.3%, P=0.0001). ALL-1 gene rearrangement was associated with significantly higher WBC count ( P=0.01) and CD10 negativity ( P=0.00000001). Complete remission (CR) and relapse rates in 98 patients evaluable for response to therapy on a uniform therapy protocol was independent of ALL-1 gene status.
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