Incidence and risk factors of spontaneous hemorrhagic transformation in cardioembolism and large artery atherosclerotic infarction

Abstract

To explore the incidence and risk factors for spontaneous hemorrhagic transformation (HT) of cardioembolism (CE, n=150) and large artery atherosclerotic infarction (LAA, n=370). The incidence of HT was 29.3% in CE. And it was significantly higher than 9.7% (P<0.05). Infarct size, low-density lipoprotein-cholesterol (LDL-C) and admission National Institutes of Health Stroke Scale (NIHSS) score were independent predictors of spontaneous hemorrhagic transformation in LAA. OR values were 3.92, 2.96 and 1.45 respectively. Infarct size, admission NIHSS score and random blood glucose level were independent predictors of spontaneous hemorrhagic transformation in CE. OR values were 4.86, 2.42 and 1.42 respectively. As compared with LAA, CE was more prone to HT. LAA and CE-related factors of hemorrhagic transformation are not completely identical. Key words: Cerebral infarction; Spontaneous hemorrhagic transformation; Risk factors