Abstract
BackgroundThe purpose of this study was to determine risk factors of postoperative complications in tuberculosis-destroyed lung (TDL) patients.MethodsWe retrospectively analyzed the data from all consecutive TDL patients undergoing surgical treatment at the Beijing Chest Hospital from January 2001 to September 2019.ResultsOf 113 TDL cases experiencing surgery, 33 (29.2%) experienced postoperative complications. The patients with low BMI were more likely to have postoperative complications compared to those with normal BMI, whereas a significant lower rate of postoperative complications was noted in patients with BMI ≥ 25 kg/m2. In addition, significant increased risk was observed in patients with smoking history. We found that the patients with underlying infection, including aspergillus and nontuberculous mycobacteria (NTM), had significantly higher odds of having postoperative complications compared with those without underlying infection. The anaemia was another important independent factor associated with postoperative complication. Patients with blood transfusion above 1000 mL had a strongly increased frequency of postoperative complications than patients with blood transfusion below 1000 mL.ConclusionIn conclusion, our data demonstrate that approximate one third of TDL patients experience postoperative complications in our cohort. Patients with low BMI, anaemia, tobacco smoking, and coinfected aspergillus or NTM are at markedly higher risk to experience postoperative complications after pneumonectomy.
Highlights
Tuberculosis (TB) remains a significant cause of global morbidity and mortality [1, 2].In 2019, 10.0 million people developed TB and 1.4 million people died from the disease, with most cases in developing countries [1]
The patients with low Body Mass Index (BMI) were more likely to have postoperative complications compared to those with normal BMI [adjusted odds ratio: 6.333, 1.957–20.500], whereas a significant lower rate of postoperative complications was noted in patients with BMI ≥ 25 kg/m2
Heaviness of smoking index had no impact on the presence of postoperative complications, significant increased risk was observed in patients with smoking history
Summary
Tuberculosis (TB) remains a significant cause of global morbidity and mortality [1, 2].In 2019, 10.0 million people developed TB and 1.4 million people died from the disease, with most cases in developing countries [1]. Despite great achievement in TB control over. Pulmonary TB can cause variable changes in pulmonary parenchyma, ranging from pulmonary infiltrate to parenchymal lung devastating [5]. Tuberculosis-destroy lung (TDL) is one of the most devasting sequelae of TB [6]. Decreased lung and airway volume in patients with TDL are associated with progressive lung function decline, respiratory failure and pulmonary disabilities [6]. Despite resulting in fatal outcomes, there is no formal. The purpose of this study was to determine risk factors of postoperative complications in tuberculosisdestroyed lung (TDL) patients
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