Abstract
<i>Background</i>: Peripherally inserted central catheter (PICC) is widely used all over the world, but the complications related to it have not been well solved. <i>Objective</i>: To evaluate PICC-related complications and risk factors. <i>Methods</i>: We conducted a retrospective study at multicenters on patients who underwent PICC placement from May 2017 to June 2018 to identify the incidence and risk factors of complications. Information of patients and insertion was collected by an mobile App. Univariable and multivariable analysis were fit to examine the risk factors of complications. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to indicate the association between risk factors and complications. <i>Results</i>: A total of 4959 patients were included with 511 (10.3%) patients developed complications. In univariable analysis, age (<I>P</I>=0.026), smoke (<I>P</I><0.001), drinking (<I>P</I><0.001), prior surgery (<I>P</I><0.001) and PICC insertion site (<I>P</I>=0.023) were associated with complications. Following logistic regression analysis, drinking (OR 1.72, 95 CI% 1.07-2.778, <I>P</I>=0.025) and prior surgery (OR 2.04, 95% CI 1.55-2.67, <I>P</I><0.001) remained to be independent risk factors of complications. Drinking was associated with phlebitis (<I>P</I>=0.002) and thrombosis (<I>P</I>=0.007), and prior surgery was associated with phlebitis (<I>P</I><0.001), infections (<I>P</I>=0.001) and mechanical complications (<I>P</I>=0.008). <i></i>Conclusion: Paying more attention to patients who drink alcohol and have surgery history may reduce the risk of adverse outcome.
Highlights
Peripherally inserted central catheter (PICC) are increasing used in medical practice including the infusion of total parenteral nutrition, chemotherapy and long-term intravenous fluids [1, 2] due to its safety and efficacy as long-term vascular access compared with central venous catheters (CVCs) [3, 4]
Univariable analysis showed that age (t=2.22, P=0.026), smoke (χ2=23.87, P
The main findings were as follows: 1) the incidence of PICC-related complication was 10.3% and phlebitis (27.0%), thrombosis (23.3%), infection (17.4%) accounted for the top three complication events; 2) Drinking and prior surgery history increased the risk of PICC-related complications; 3) Drinking was related to phlebitis and thrombosis, and surgery history was associated to phlebitis, infections and mechanical complications
Summary
PICCs are increasing used in medical practice including the infusion of total parenteral nutrition, chemotherapy and long-term intravenous fluids [1, 2] due to its safety and efficacy as long-term vascular access compared with central venous catheters (CVCs) [3, 4]. Previous study reported the incidence of PICC-related complications ranging from 12% to 24.7% [9,10,11,12]. Our study was performed to estimate incidence and identify risk factors of PICC-related complications. Methods: We conducted a retrospective study at multicenters on patients who underwent PICC placement from May 2017 to June 2018 to identify the incidence and risk factors of complications. Age (P=0.026), smoke (P
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