Abstract
Introduction: Early-onset sepsis (EOS) is associated with a high risk of mortality and morbidity, which are increased in preterm infants. We aim to assess the incidence and factors associated with increased risk of EOS among preterm infants. Methods: We conducted a retrospective cohort study at King Abdulaziz University Hospital, a tertiary and teaching hospital in Jeddah city. We included preterm infants <37 weeks of gestational age (GA) who were admitted to the neonatal intensive care unit. Those with congenital anomalies were excluded from the study. Results: We included 335 preterm infants, out of which 21 (6.3%) were diagnosed with EOS. Preterm infants with EOS had significantly lower GA (P < 0.001), birth weight (P = 0.024), and APGAR scores at 1 (P = 0.024) or 5 min (P = 0.007). More preterm infants with EOS were born outside the hospital (P < 0.029) and had significantly higher C-reactive protein (P = 0.016). Mortality was significantly higher in preterm infants with EOS compared to those without (42.9% vs. 7.3%, P < 0.001). Our multivariate regression analyses showed that decreased GA (P = 0.006) and delivery outside the hospital (P = 0.011) were associated with an increased risk of EOS in preterm infants. Conclusion: We identified risk factors that are significantly associated with EOS in preterm infants and should be considered to improve neonatal outcomes.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
