Incidence and Risk Factors of Diabetes Mellitus (DM) after Distal Pancreatectomy (DP): A Multivariate Analysis

Abstract

Introduction: The incidence of DM after DP ranges from 11% to 46%. Risk factors are not established. Our objective is identify risk factors for development or worsening of DM after DP of patients in Upper Digestive Surgery Group at Hospital São Rafael / Rede D’Or, Salvador, Bahia. Methods: Data were collected through standardized forms filled out prospectively between 2010 and 2021. Age, gender, comorbidities, surgical complications, tumor’s nature, extension, and thickness of removed pancreas were analyzed. Univariate analysis was performed to identify risk factors to development or worsening of DM in late postoperative period (>30days). Variables with p<0.05 were selected for multivariate analysis by logistic regression. Results: Eigthy-six patients were submitted DP. Mean age was 50.3 ± 16.3 and 71.8% were female. Were previously diabetic 13.8%. The incidence of new onset DM was 31%. In Univariate analysis, sex, age, BMI>30, comorbidities and tumor’s nature were not related to DM. Were statistically significant, the length of resected pancreas (p=0.02) and family history of DM (p=0.0001). In multivariate analysis, only family history of DM (p=0.018; OR 16.896) maintained statistical relevance. Conclusion: In our study family history was related to DM post DP. The length of resected pancreas was not related to DM post DP.