Incidence and Risk Factors for the Development of Idiopathic Pneumonitis Syndrome (IPS) after Autologous Hematopoietic Cell Transplantation (AutoHCT) for Patients with Lymphoma

Abstract

s / Biol Blood Marrow Transplant 20 (2014) S104eS127 S106 Myeloma subtype, ISS, post-ASCT response and PET activity were significantly associated with PFS. Post-ASCT PET(-) CR had significantly longer PFS than patients with PET(+) CR (31.4 9.9 vs 18.4 3.5 months; p1⁄4.029). In conclusion, having an ISS-3 stage myeloma, pre and post-ASCT response <VGPR had negative impact on PFS. Contamination of PBSC harvests with APC was associated with shorter PFS. Our results also demonstrate the importance of achieving PET negativity after transplantation. Thus, not only an immunological CR but also PET(-) CR should be achieved for long term PFS.