Abstract
BackgroundEribulin is a microtubule inhibitor, which is approved for the treatment of breast cancer. Peripheral neuropathy has been reported in the studies of eribulin, but the incidence and relative risk (RR) of eribulin-associated peripheral neuropathy varied greatly in cancer patients. The purpose of this meta-analysis was to determine the overall incidence and RR of eribulin-associated peripheral neuropathy in cancer patients.Materials and MethodsPubmed database and Embase and abstracts presented at the American Society of Clinical Oncology (ASCO) meetings were systematically reviewed for primary studies. Eligible studies included prospective clinical trials and expanded access programs of cancer patients treated with eribulin. Statistical analyses were performed to calculate the incidences, RRs, and 95% confidence intervals (CIs).ResultsAltogether, 4,849 patients from 19 clinical trials were selected for this meta-analysis. The incidences of all-grade and high-grade peripheral neuropathy were 27.5% (95% CI: 23.3–32.4%) and 4.7% (95% CI: 3.6–6.2%), respectively. The relative risks of peripheral neuropathy of eribulin compared to control were increased for all-grade (RR = 1.89, 95% CI: 1.10–3.25) but not statistically significant for high-grade (RR = 2.98, 95% CI: 0.71–12.42).ConclusionsThe use of eribulin is associated with an increased incidence of peripheral neuropathy. The RR is increased for all-grade peripheral neuropathy.
Highlights
Eribulin mesylate (E7389) is a synthetic analog of halichondrin B, which is a nontaxane microtubule inhibitor, isolated from the rare marine sponge Halichondria okadai [1]
Materials and Methods: Pubmed database and Embase and abstracts presented at the American Society of Clinical Oncology (ASCO) meetings were systematically reviewed for primary studies
The incidences of all-grade and high-grade peripheral neuropathy were 27.5% and 4.7%, respectively
Summary
Eribulin mesylate (E7389) is a synthetic analog of halichondrin B, which is a nontaxane microtubule inhibitor, isolated from the rare marine sponge Halichondria okadai [1]. Eribulin was approved for the treatment of metastatic breast cancer patients who have received two chemotherapeutic regimens previously. Chemotherapyinduced peripheral neuropathy (CIPN) is one of the major toxicities, which will lead to a significant decrease in the patient’s quality of life. Eribulin is a microtubule inhibitor, which is approved for the treatment of breast cancer. Peripheral neuropathy has been reported in the studies of eribulin, but the incidence and relative risk (RR) of eribulin-associated peripheral neuropathy varied greatly in cancer patients. The purpose of this meta-analysis was to determine the overall incidence and RR of eribulin-associated peripheral neuropathy in cancer patients
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