Abstract
Malignancy, surgical resection, and neoadjuvant and/or adjuvant chemotherapy increase the low-extremity deep vein thrombosis (LDVT) risk in patients with breast cancer, bringing in great physical burdens, disabilities, and worse survivals. However, LDVT in surgical breast cancer patients is scarcely reported. Therefore, this study aimed to evaluate the incidence and related factors for LDVT in these patients. Patients with breast cancer who underwent surgical resection were included. LDVT was examined on the day of discharge and 1 month after the discharge. A total of 491 eligible patients were included, among which 11 (2.2%) patients occurred LDVT. Besides, higher age, history of diabetes mellitus, advanced T and tumor node metastasis (TNM) stages, higher platelet count, and shorter activated partial thromboplastin time (APTT) were correlated with increased LDVT incidence (all p < 0.05). Additionally, higher age [p = 0.004, odds ratio (OR) (95% CI): 1.082 (1.023–1.144)], history of diabetes mellitus [p = 0.003, OR (95% CI): 10.426 (2.219–48.986)], and a higher platelet count [p = 0.008, OR (95% CI): 1.017 (1.004–1.029)] were independent factors for increased LDVT incidence, while higher APTT [p = 0.004, OR (95% CI): 0.636 (0.467–0.866)] was an independent factor for decreased LDVT incidence. Lastly, the risk prediction model involving age, history of diabetes mellitus, platelet count, and APTT showed a good ability to predict LDVT occurrence (area under curve: 0.919, 95% CI: 0.869–0.968). In conclusion, the LDVT incidence is 2.2%, and its independent factors consist of age, history of diabetes mellitus, platelet count, and APTT in patients with breast cancer who underwent surgical resection, which provides evidence for the prevention and surveillance of LDVT in surgical breast cancer.
Highlights
Breast cancer is the most common carcinoma and a leading cause of cancer mortality in women, with ∼2,000,000 new cases and 626,000 fatalities globally every year [1, 2]
The primary findings were listed as follows: in 491 patients with breast cancer who underwent surgical resection, (i) the incidence of low-extremity deep vein thrombosis (DVT) (LDVT) was 2.2%, (ii) higher age, history of diabetes mellitus, and higher platelet count were independent factors for higher LDVT incidence, while higher activated partial thromboplastin time (APTT) was an independent factor for lower LDVT incidence, (iii) the risk prediction model involving age, history of diabetes mellitus, platelet count, and APTT showed a good ability to predict LDVT occurrence
Lipid, and coagulation indexes, the present study discovered that in patients with breast cancer who underwent surgical resection, higher platelet count was an independent factor for higher LDVT incidence, while higher APTT was an independent factor for lower LDVT incidence within 1 month after discharge from the hospital
Summary
Breast cancer is the most common carcinoma and a leading cause of cancer mortality in women, with ∼2,000,000 new cases and 626,000 fatalities globally every year [1, 2]. Great progress has been made on the treatments for breast cancer, such as surgical resection, neoadjuvant therapy, adjuvant therapy, endocrinotherapy, and targeted therapy [3,4,5,6,7]. Among these treatments, resection is a predominant strategy. One of the most threatening complications is deep vein thrombosis (DVT), a severe disease in the venous system, which is a vital cause of high mortality of breast cancer [10, 12, 13]. It is worth noting that patients with LDVT often suffer from physical burdens, such as Neuh of positive and Homans signs, superficial varicosities, stasis pigmentation, edema and pain of lower limbs, and low-extremity paralysis, resulting in treatment difficulty, reduced quality of life, worse survivals, or sudden death [9, 20,21,22,23,24,25]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
