Abstract
Incidence and pathogenesis of skin tumours in mice irradiated with single external doses of low energy beta particles.
Highlights
MethodsThe method of Crook, Hulse, Mulvey and Neary (1958) was used. 204T1 was incorporated into an open-ended cylindrical foil 1.1 cm. long and 2-5 cm. in diameter
Some seemed to have started as fibromas but the majority appeared to arise as sarcomas de novo
Part-body external irradiation of CBA mice with doses of 204T1 beta particles gave a high incidence of skin tumours but did not otherwise shorten life
Summary
The method of Crook, Hulse, Mulvey and Neary (1958) was used. 204T1 was incorporated into an open-ended cylindrical foil 1.1 cm. long and 2-5 cm. in diameter. The method of Crook, Hulse, Mulvey and Neary (1958) was used. 204T1 was incorporated into an open-ended cylindrical foil 1.1 cm. The mice were placed in a thin-walled celluloid tube of the same diameter which was adjusted within the cylindrical foil. The mice fitted snugly within the celluloid tubes and their fur was lightly compressed against the sides. As the head was never irradiated, the area of skin exposed to the ,.'32. Source was the same size as the 204T1 cylindrical foil, i.e. 8.6 cm.. Source was the same size as the 204T1 cylindrical foil, i.e. 8.6 cm.2 Such an exposed area of skin will be referred to as an irradiated zone. The mice were supplied with a current of fresh air throughout the irradiation
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