Abstract
ObjectiveTo analyze the incidence and mortality rates of thyroid cancer (TC) in China from 2008 to 2012.MethodsIncident and death cases of TC were retrieved from the National Central Cancer Registry (NCCR) database collecting from 135 cancer registries in China during 2008−2012. The crude incidence and mortality rates of TC were calculated by area (urban/rural), region (eastern, middle, western), gender and age group (0, 1−4, 5−9, …, 85+). China census in 2000 and world Segi’s population were applied for age-standardized rates. Joinpoint (Version 4.6.0.0) model was used for time-trend analysis.ResultsThe crude incidence rate of TC was 7.56/100,000 which ranked the seventh in overall cancers. The age-standardized incidence rates by China population (ASIRC) and by World population (ASIRW) were 6.25/100,000 and 5.52/100,000, respectively. The crude mortality of TC in China was 0.52/100,000. The age-standardized mortality rates by Chinese standard population (ASMRC) and by world standard population (ASMRW) were 0.34/100,000 and 0.32/100,000, respectively. Incidence and mortality rates of TC were higher in females than in males and higher in urban areas than in rural areas. Eastern areas had the highest incidence followed by middle and western areas. TC incidence increased dramatically after age of 15 years, then peaked at 14.08/100,000 in the group of 50−54 years and finally decreased sharply after 55 years old. TC mortality increased with age in population, reaching the peak of 5.09/100,000 in sub-population aged 85 years or older. TC incidence increased by 4.73 times from 2.40/100,000 in 2003 to 13.75/100,000 in 2012 with an average annual increase of 20%, while TC mortality only increased slightly around 0.32/100,000 from 0.26/100,000 to 0.36/100,000.ConclusionsAppropriate targeted prevention, early detection and treatment programs can be carried out to curb the rapid growth trend of TC and control the disease burden.
Highlights
Thyroid cancer (TC) is the most common head and neck malignancy of the endocrine system
In order to eliminate the influence of annual random change of rates and guarantee the stability of statistical results, we described the epidemic characteristics of TC in China to provide basic information for the control and research of TC, using a 5-year consolidated database pooled during 2008 to 2012
There was an estimate of 47,550 new TC cases diagnosed in China during 2008−2012, accounting for 2.67% of all new cancer cases
Summary
Thyroid cancer (TC) is the most common head and neck malignancy of the endocrine system. In the past 30 years, except for Africa where disease diagnosis technology is limited, the rapid increase of TC incidence in the world has aroused widespread concern. China is 12.40/100,000 in 2014, becoming one of the increasing fastest malignant tumors [1]. According to the world cancer report (GLOBOCAN 2012), the global estimated incidence of TC in 2012 was 298,102 cases and 39,771 deaths [2]. In order to eliminate the influence of annual random change of rates and guarantee the stability of statistical results, we described the epidemic characteristics of TC in China to provide basic information for the control and research of TC, using a 5-year consolidated database pooled during 2008 to 2012
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