Incidence and Mortality of Multiple Myeloma in China, 2006-2016: An Analysis of the Global Burden of Disease Study 2016

Abstract

Background: The accurate information about burden of multiple myeloma (MM) at national and provincial level remain unknown in China. Methods: We used data from the Global Burden of Disease Study 2016 (GBD 2016) to calculate the burden of MM and to describe the temporal trend in China. Findings: It was estimated that there were 16 500 new cases and 10 300 deaths of multiple myeloma in China. The age-standardized incidence rates (ASIR) and mortality rates (ASMR) per 100 000 population were 1.03 (95%UI, 0.88-1.17) and 0.67 (95%UI, 0.59-0.77). Males had higher incidence and mortality rates than females in all age groups. An upward trend with age in incidence and mortality were observed. Furthermore, higher incidence and mortality rates clustered in those developed provinces. The incidence of MM in China increased significantly from 2006 to 2016, while the mortality increased from 2006 to 2014, and then remained stable from 2014 to 2016. Interpretation: The burden of MM had a heterogeneous pattern in China, which highlighted the need of differentiated disease prevention and control strategies in both national and provincial levels. Funding Statement: China Special Program for Basic Research 2014 from Ministry of Science and Technology (Grant number: 2014FY121100). Declaration of Interests: The authors declare no competing interests. Ethics Approval Statement: Not required.