Abstract
ObjectiveTo analyze the incidence and mortality rates of corpus uteri cancer in China using 2008−2012 data from the National Central Cancer Registry (NCCR) of China.MethodsWe analyzed 2008−2012 data from 135 cancer registries using NCCR screening methods and criteria. The Chinese standard population in 2000 and Segi’s world population were applied to determine age-standardized incidence and mortality rates. The annual percentage change (APC) in rate was calculated using the Joinpoint Regression Program.ResultsThe crude incidence of corpus uteri cancer was 9.58/100,000, making corpus uteri cancer the ninth most common malignancy in females. The crude mortality was 2.97/100,000, making corpus uteri cancer the 13th leading cause of death from malignant tumors in females. The incidence was higher in urban than in rural areas, but the mortality was higher in rural than in urban areas. The crude incidence was higher in eastern areas than in middle and western areas, while the crude mortality was higher in middle areas than in eastern and western areas. During 2003−2012, the age-standardized incidence rate based on the Chinese standard population in 2000 (ASIRC) with uterine cancer increased significantly by 3.0% annually, while the age-standardized mortality rate based on the Chinese standard population in 2000 (ASMRC) decreased by 0.4% annually, but the decrease was not statistically significant. The APC in incidence rate in the age groups of 30−44 years was 4.2%, which was statistically significant; increases/decreases in other age groups were not statistically significant. From 2003 to 2004, the age groups of 60−74 years showed high incidence, while from 2005 to 2012, the age groups of 45−59 years had high incidence.ConclusionsThe incidence and mortality rates of corpus uteri cancer in China from 2008 to 2012 were relatively low compared with other countries. However, the significant increase in incidence rates and marked decrease in patient age suggest the need to strengthen China’s efforts toward prevention and control of corpus uteri cancer.
Highlights
Corpus uteri cancer is one of the most common gynecological cancers in females
We used the data collected from the National Central Cancer Registry (NCCR) of China during 2008−2012 to analyze the epidemic situation of corpus uteri cancer in tumor registration areas of China during this period
ASIRC; age-standardized incidence rate based on the Chinese standard population in 2000; APC, annual percentage change; 95% CI, 95% confidence interval; *, P
Summary
Corpus uteri cancer is one of the most common gynecological cancers in females. In 2013, it accounted for. Studies have shown an increasing trend in the incidence and mortality rates of corpus uteri cancer, with the incidence in developed countries and regions exceeding. With the rapid socioeconomic development, lifestyle changes, urbanization, and aggravated population aging in China, the incidence of corpus uteri cancer has exhibited an increasing trend, posing a serious threat to females’ health. According to estimates by GLOBOCAN 2012, the age-standardized (world population-based) incidence rate and mortality rate of corpus uteri cancer in China are 8.6/100,000 and 1.9/100,000, respectively, thereby ranking corpus uteri cancer as the 9th most common malignant tumor and 13th most common cause of cancer-related death in women [2]. We analyzed incidence and mortality trends of corpus uteri cancer during the 10-year period from 2003 to 2012. Our results would provide a scientific basis for the formulation of China’s prevention and control strategies toward corpus uteri cancer and the evaluation of effects of such efforts
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