Abstract
The guidelines recommendation for protein dose in critically ill patients is 1.2 - 2.0 g/kg/d. Despite this recommendation, the actual amount delivered ranks between 0.5 and 3.8 g/kg/d therefore there is significant controversy in the amount of protein prescribed and delivered worldwide. This review approachthe clinical equipoise, or a state of genuine uncertainty about two (dosing) strategies for protein dose. In addition, highlight the limited contribution of Latin American (LATAM) patients in published Randomized Clinical Trials (ECAs) questioning the generalizability of their results. This manuscript outline evidencefor and against high protein dose and introduce the EFFORT trial which aims to answer the important question of what protein dose is the best for what type of patient?
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