Abstract
AbstractA convenient and environmentally benign protocol for Michael addition has been developed using water extract of incense sticks ash (WEISA) at room temperature. This is the first report to utilize WEISA as an effective and renewable medium for the formation of C−C and C−S bonds via Michael addition of readily available chalcones and various nucleophiles like malononitrile, benzyl cyanide, nitromethane and thiols. WEISA is generated from waste material, therefore, the present development is eco‐friendly and cost‐effective. The corresponding Michael adducts were isolated with high yields by simple precipitation and sequential washing with aqueous ethanol; avoids the extraction and column chromatographic purification steps. The other significant features of the developed protocol are the clean reaction profile, high functional group tolerance, large‐scale synthesis, and reusability of reaction media. Additionally, a straightforward application of this methodology is shown in the synthesis of biologically relevant 2‐amino‐4H‐chromene derivatives.
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