Abstract
Background . Pediatric skin melanoma is very rare, it differs in a number of features from adult skin melanoma. Early diagnostics of this highly malignant tumor is a key prerequisite for effective treatment. The same methods are commonly used which are applied for diagnostics of adult melanoma in the course of diagnostics of skin melanoma in children. Appropriateness of this approach deserves validation. The aim of this work is to describe procedures of diagnostics of a pigment skin malformation in a child. Case report . Girl aged 5 months entered pediatric clinic of the FSBI “N.N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation with inborn tumor in a wrist joint area. Hemangioma had been suggested formerly at residence place. In the course of diagnostics in N.N. Blokhin National Medical Research Center of Oncology the following complex of approaches was used: ultrasound scanning, magnetic resonance imaging, trepanobiopsy, open biopsy. Tissues from the latter were examined histologically on hematoxylin and eosin — stained slides. Immunohistochemical study was also done by means of revelation of determinants of cell proliferation, antigens of melanocytic differentiation, proteins commonly used as strictly melanoma markers as well as antigens of tissue compatibility. The conclusion was done about nodular pigment cell skin melanoma. Excision of the tumor was carried out. Relapse-free period lasts for 12 months at present. Conclusion . Procedures are described of diagnostics and treatment of a 5-month-old girl with skin melanoma in a wristjoint area. In the course of diagnostics approaches were used which are commonly applied when identifying a more frequent and better explored adult skin melanoma. Prolongation of studies is desirable to validate these approaches for diagnostics of pediatric pigment skin tumors.
Highlights
Pediatric skin melanoma is very rare, it differs in a number of features from adult skin melanoma
The same methods are commonly used which are applied for diagnostics of adult melanoma in the course of diagnostics of skin melanoma in children
Immunohistochemical study was done by means of revelation of determinants of cell proliferation, antigens of melanocytic differentiation, proteins commonly used as strictly melanoma markers as well as antigens of tissue compatibility
Summary
Меланома кожи у детей встречается очень редко и по ряду характеристик отличается от меланомы кожи у взрослых. Ранняя диагностика этой высокозлокачественной опухоли является главным условием успешного лечения. При определении заболевания у детей обычно используют те же методы, что и у взрослых. Цель исследования – описание процедур постановки диагноза для крупного врожденного пигментного новообразования кожи у ребенка. Описание клинического случая врожденной опухоли в области лучезапястного сустава у девочки 5 мес. При диагностике в НИИ детской онкологии и гематологии НМИЦ онкологии им. Описаны процедуры диагностики и лечения 5‐месячной девочки с врожденным пигментным новообразованием кожи в области лучезапястного сустава. В процессе диагностики использованы подходы, применяемые при выявлении более частой и лучше изученной меланомы кожи у взрослых. Для подтверждения адекватности использованных в работе методов в диагностике пигментных новообразований кожи у детей целесообразно продолжение исследований. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russia; 24 Kashirskoe Sh., Moscow 115478, Russia; 2Department of Pathological Anatomy, Russian Medical Academy of Continuous Professional Education of the Ministry of Health of Russia; 12 / 13 Polikarpova St., Moscow 125284, Russia
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.