INAPPROPRIATE LEFT VENTRICULAR MASS IN YOUNG HYPERTENSIVE MEN: PP.22.368

Abstract

Objective: Evaluation of the proportionality of left ventricular mass (LVM) with the systolic blood pressure (BP) level, height and sex has high perspective for the evaluation of LV remodeling. Aim of the study is to evaluate the frequency of inappropriate LV mass in young hypertensive men. Methods: Echocardiography (VIVID 7, GE) was performed in three groups of men of 18–25 years old (average age 20,9 ± 2,0 years): 74 with sustained AH, 45 with non-sustained AH, and 26 normotensive subjects. The groups were matched on age, height, weight. Lipids and glucose levels were similar also. BP status was assessed with repeated clinic measurement and ambulatory BP monitoring. Observed LVM was calculated in 2D-mode by modified ASE-cube formula and indexed to the body surface area. Predicted LVM was calculated using de Simone et al. formula. The observed/ predicted LVM ratio >128% was considered as inappropriate high LVM, and < 73% - as inappropriate low LVM. The data are shown as M ± SD. Results: In subjects with sustained AH LVM was 201,2 ± 18,0 g, LVMI 97,6 ± 17,1 g/m2, in subjects with non-sustained AH 172,2 ± 35,1 g and 85,1 ± 15,2 g/m2, respectively, in normotensives 152,0 ± 17,0 g and 73,7 ± 8,5 g/m2, respectively. Observed/ predicted LVM ratio in sustained AH was 118,4 ± 8,2, non-sustained AH 103,0 ± 10,1, in normotensives 98,8 ± 11,2. LVM, LVMI and observed/ predicted LVM ratio were significantly higher in those with sustained AH than in normotensive subjects (p < 0,01). No inappropriately low LVM was revealed in all three groups. LV hypertrophy by ESH 2007 criteria and inappropriately high LVM were revealed only in subjects with sustained AH in 6,7% and 18,9%, respectively. Conclusion: The phenomenon of inappropriately high LVM may be the early sign of the heart remodeling in young men with sustained arterial hypertension.