Abstract
THE SYNDROME of inappropriate antidiuretic hormone (SIADH) secretion is characterized by serum hyponatremia and hyposmolality associated with relative urinary hyperosmolality and excessive renal salt loss; there is an absence of clinical evidence of fluid volume depletion, and renal and adrenal function are normal. 1 The subject of this report, a child with a hypothalamic glioma, fulfilled all of these criteria and, in addition, showed several atypical features of the SIADH. These included a normal response to an acute water load, the occasional failure to respond to severe water restriction, and the discontinuous secretion of a measurably elevated ADH co-existing with persistent hyponatremia. These features are not inconsistent with the inappropriate secretion of ADH. A possible alternative explanation is that a malfunctioning hypothalamic osmostat may be an associated defect. Report of a Case This 6-year-old boy was hospitalized on Oct 19, 1968, because of headaches and vomiting of several
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
