Abstract
Ewes, immunized with conjugates of 17β-estradiol hemisuccinate coupled to bovine serum albumin, produce antisera capable of neutralizing the hormone in vitro and in vivo. The antibodies inhibited the biological effects produced by estradiol administered to immature or mature ovariectomized rats and mice. Furthermore, they prevented uterine weight increases, endometrial stimulation and vaginal cornification due to endogenous estrogens following treatment with human chorionic gonadotropin. Pretreatment of intact animals with antisera inhibited the uptake by uteri, pituitaries and ovaries of tritiated estradiol administered subcutaneously.The antibodies did not inhibit the uterine stimulation caused by administration of diethylstilbestrol. Antibodies to estradiol did not counteract androgenic effects upon accessory sex organs produced by testosterone administered to immature male rats. Nor did antibodies elicited by testosterone-protein conjugates alter the effects of 17β-estradiol in immature rats. Contrary...
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