Abstract
Lung cancer is the leading cause of cancer-associated mortality worldwide. In the last two decades
Highlights
To address JNK1/2 as major suppressors for Lkb1-dependent Lung squamous cell carcinoma (SCC) (LSCC) initiation and progression, the authors conducted in vitro and in vivo investigations by ablating JNK1/2 in mLSCC cells and knocking JNK1/2 out in Lkb1 deficiency mice
Lung cancer can be classified as two major subtypes, namely adenocarcinoma (ADC) and squamous cell carcinoma (SCC), together they account for more than 80% of cases
The process of tumorigenesis was accelerated to 7-8 months when Jnk1d /d / Jnk 2−/− was combined and a 100% penetrance of LSCC and its initial lesions was achieved!
Summary
Lung cancer can be classified as two major subtypes, namely adenocarcinoma (ADC) and squamous cell carcinoma (SCC), together they account for more than 80% of cases. More than 50% of lung cancers showed a mix of the subtypes indicating a high degree of heterogeneity of these tumors [1,2], the ADC and SCC are shown to possess a distinct pattern of genomic abnormalities [3,4]. By mimicking genomic alterations of human cancer in mice, the whole process of tumorigenesis from initial to advanced stages can be dissected and studied in a spatial and temporal manner.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biomedical Journal of Scientific & Technical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
