Abstract
The activity of proteinase inhibitors of guinea-pig serum was evaluated by using trypsin as test enzyme. Strains of black-pigmented Bacteroides species were incubated with serum under anaerobic conditions. Strains of Bacteroides gingivalis inactivated the trypsin inhibitors of guinea-pig serum within 1 h, while the other strains reduced the activity of the trypsin inhibitors by less than 50% within 48 h. The inactivation of proteinase inhibitors of guinea-pig serum by B. gingivalis may be an important pathogenic mechanism in the spreading necrotic infections induced in guinea pigs by pure cultures of this species.
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