Abstract
We have studied the effect of sodium fluoride and sodium molybdate on temperature-dependent inactivation of the chick oviduct progesterone receptor. Both fluoride and molybdate stabilize the receptor's hormone-binding capacity in crude cytosol at 25° and 30°C. However, no protective effect is seen when receptors have first been dissociated by KCl treatment, ammonium sulfate fractionation, or exhaustive dialysis. Furthermore, sucrose gradient analysis reveals that molybdate and fluoride stabilize progesterone receptors in the aggregate form. We conclude that these ions may be acting not on a phosphatase in the cytosol, but directly on the receptor itself.
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