Abstract
The variegated position-effect for Pgd locus coding for 6-phosphogluconate dehydrogenase (PGD) in Drosophila melanogaster has been studied. Transposition of the left end of the X-chromosome carrying the Pgd locus to the proximal heterochromatin of the same chromosome in a Dp(1;f)R rearrangement results in the inactivation of Pgd locus. The elimination of the Y-chromosome and a decrease of the temperature at which the flies developed resulted in a strong enhancement of inactivation of the Pgd locus—the total activity of enzyme in the crude extracts of flies was significantly reduced. Decrease of the activity of the electrophoretically fast form of PGD coded for by the PgdA allele in the rearrangement was observed while the activity of the homologous locus in the normal X-chromosome of the same individual remained unaffected. A decrease of PGD activity was correlated with the extent of variegated position-effect for adjacent genes (sc, dor and pn) whose inactivation could be visually estimated.
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