Abstract

Inactivation and Disinfection of Poliovirus Type 1 on Nonporous Carriers

Highlights

  • Poliovirus is a clinically relevant enterovirus from the Picornaviridae family of non-enveloped viruses

  • We have evaluated the efficacy compared with that of solutions of sodium hypochlorite. of three disinfectants against poliovirus type 1 (PV-1) deposited on glass carriers Table 1: Properties and mechanisms of action of the products evaluated

  • The efficacies of Microbide-S, Microbide-G, and sodium hypochlorite for inactivating PV-1 deposited on glass carriers in the presence of low organic load (5% fetal bovine serum (FBS)) were evaluated at ambient temperature (21 °C)

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Summary

Introduction

Poliovirus is a clinically relevant enterovirus from the Picornaviridae family of non-enveloped viruses. Prior to the introduction of inactivated and attenuated poliovirus vaccines in the 1950’s, the virus caused considerable global panic from 1890 onward [1]. Enteroviruses, including polioviruses, are viruses which are transmitted through the oral/fecal route. Oral secretions and fecal excretions from infected individuals are capable of infecting new hosts via the gastrointestinal tract of a noninfected individual. Interruption of the cycle of infection and reinfection of enteroviruses may be facilitated by disinfection interventions that are capable of inactivating the virus. In order to be of practical use, such disinfectants should cause a significant reduction in pathogen load on environmental surfaces (fomites) under ambient conditions following a relatively short contact time

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