Abstract

Modified nucleotides, including phosphoramidates and mesyl nucleotides, are very effective in inactivating gene expression in bacteria. Gyr A is the target gene in several organisms, including Plasmodium falciparum. Antisense reactions with bacteria infecting citrus plants are promising but incomplete. Human tissue culture cells assayed with a different target are also susceptible to the presence of mesyl oligonucleotides.

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Topics from this Paper

  • Gene Expression In Bacteria
  • Target Gene
  • Human Culture
  • Human Cells
  • Human Tissue Culture Cells
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Acta Naturae