Year-end Sale % OFF 
Abstract
We have read with interest recent reports of the measurement of free thyroxine and free triiodothyronine by ultrafiltration and tandem mass spectrometry (1)(2)(3)(4). There is, however, a fundamental flaw in these studies that we wish to bring to general attention. Ultrafiltration of serum was routinely carried out close to room temperature (25 °C)(1 …
Highlights
Decision-making regarding PCT results has been based on relative PCT concentrations rather than absolute cutoff points, taking into account patient day-today variations (1 )
We conclude that method comparison should focus on concentration intervals relevant for clinical purposes and that the observed differences in interassay transferability should not withhold introduction of the PCT assay on a routine immunochemistry analyzer family
Role of Sponsor: The funding organizations played no role in the design of study, choice of enrolled patients, review and interpretation of data, or preparation or approval of manuscript
Summary
Scattered; Ͼ95% of the differences were within the levels of agreement (defined by bias Ϯ 1.96 SD). Decision-making regarding PCT results has been based on relative PCT concentrations rather than absolute cutoff points, taking into account patient day-today variations (1 ). With this shift toward PCT trend analysis, precision criteria might outweigh criteria for accuracy, putting the current discussion on interassay differences into another perspective. We conclude that method comparison should focus on concentration intervals relevant for clinical purposes and that the observed differences in interassay transferability should not withhold introduction of the PCT assay on a routine immunochemistry analyzer family. Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
