Abstract
Preparations of the herb, goldenseal, have been used in an attempt to thwart detection of morphine in urine of human addicts and racing horses. To assess the potential of goldenseal to interfere with equine drug detection, horses were dosed with morphine (0.1 mg/kg IV) and, in one experimental series, also with goldenseal (60 mg/kg, p.o.). Goldenseal resulted in significant increases in urine volume, specific gravity and acidity. A significant decrease in total morphine excreted occurred 5–6 hours after dosing. It was concluded that with inclusion of an efficient hydrolysis step in the analysis, goldenseal was unlikely to interfere with urine tests for morphine, even if water loading was included in the dosing regimen.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
