In Vivo-Restricted and Reversible Malignancy Induced by Human Herpesvirus-8 KSHV: A Cell and Animal Model of Virally Induced Kaposi's Sarcoma

Abstract

(Cancer Cell 11, 245–258; March 2007) In Figure 6B of this article, there is an error in the list of the selected upregulated genes. Downregulated genes (shown in blue) were inadvertently repeated within the upregulated gene list (shown in red). We have now corrected the upregulated gene list in Figure 6B. In Vivo-Restricted and Reversible Malignancy Induced by Human Herpesvirus-8 KSHV: A Cell and Animal Model of Virally Induced Kaposi's SarcomaMutlu et al.Cancer CellMarch 13, 2007In BriefTransfection of a Kaposi's sarcoma (KS) herpesvirus (KSHV) Bacterial Artificial Chromosome (KSHVBac36) into mouse bone marrow endothelial-lineage cells generates a cell (mECK36) that forms KS-like tumors in mice. mECK36 expressed most KSHV genes and were angiogenic, but they didn't form colonies in soft agar. In nude mice, mECK36 formed KSHV-harboring vascularized spindle cell sarcomas that were LANA+/podoplanin+, overexpressed VEGF and Angiopoietin ligands and receptors, and displayed KSHV and host transcriptomes reminiscent of KS. Full-Text PDF Open Archive